The Jiang Lab

Department of Chemistry and Biochemistry

The University of Texas at Dallas

44. Picard, L. W.; Jiang, Z.*
Aptamer-conjugation Targets Decoy-ODN-therapeutics to Liver Fibrosis.
Molecular Therapy Nucleic Acids 2025, 36, 102660.
DOI: 10.1016/j.omtn.2025.102660

43. Jiang, Z.*; Kuo, Y.-H.; Arkin, M. R.*
Synthetic Autophagy Receptor.
Autophagy 2024, 20, 701–703.
DOI: 10.1080/15548627.2023.2278954

42. Jiang, Z.*; Kuo, Y.-H.; Arkin, M. R.*
Autophagy Receptor-Inspired Antibody-Fusion Proteins for Targeted Intracellular Degradation.
Journal of the American Chemical Society 2023, 145, 23939–23947.
DOI: 10.1021/jacs.3c05199
(Featured as Front Cover)

41. Jiang, Z.; Kuo, Y.-H.; Zhong, M.; Zhang, J.; Zhou, X. X.; Xing, L.; Wells, J. A.; Wang, Y.; Arkin, M. R.
Adaptor-specific Antibody Fragment Inhibitors for the Intracellular Modulation of p97 (VCP) Protein-Protein Interactions.
Journal of the American Chemical Society 2022, 144, 13218–13225.
DOI: 10.1021/jacs.2c03665

40. Tang, Y.; Kay, A.; Jiang, Z.; Arkin, M. R.
LC3B Binds to the Autophagy Protease ATG4b with High Affinity Using a Bipartite Interface.
Biochemistry 2022, 61, 2295–2302.
DOI: 10.1021/acs.biochem.2c00482
(Featured as Front Cover)

39. Jiang, Z.; Liu, H.; He, H.; Yadava, N.; Chambers, J. J.; Thayumanavan, S.
Anionic Polymers Promote Mitochondrial Targeting of Delocalized Lipophilic Cations.
Bioconjugate Chemistry 2020, 31, 1344–1353.
DOI: 10.1021/acs.bioconjchem.0c00079
(Featured as Front Cover)

38. Jiang, Z.; Liu, H.; He, H.; Ribbe, A. E.; Thayumanavan, S.
Blended Assemblies of Amphiphilic Random and Block Copolymers for Tunable Encapsulation and Release of Hydrophobic Guest Molecules.
Macromolecules 2020, 53, 2713–2723.
DOI: 10.1021/acs.macromol.9b02595

37. Jiang, Z.; He, H.; Liu, H.; Thayumanavan, S.
Azide-terminated RAFT polymers for Biological Applications.
Current Protocols in Chemical Biology 2020, 12(4), e85.
DOI: 10.1002/cpch.85
(Featured as Front Cover)

36. Jiang, Z.; Thayumanavan, S.
Non-cationic Material Design for Nucleic Acid Delivery.
Advanced Therapeutics 2020, 3, 1900206.
DOI: 10.1002/adtp.201900206

35. Jiang, Z.; Thayumanavan, S.
Disulfide-containing Macromolecules for Therapeutic Delivery.
Israel Journal of Chemistry 2020, 60, 132–139.
DOI: 10.1002/ijch.201900160

34. Jiang, Z.; He, H.; Liu, H.; Thayumanavan, S.
Cellular Uptake Evaluation of Amphiphilic Polymer Assemblies: Importance of Interplay between Pharmacological and Genetic Approaches.
Biomacromolecules 2019, 20, 4407–4418.
DOI: 10.1021/acs.biomac.9b01073

33. Jiang, Z.; Cui, W.; Prasad, P.; Touve, M. A.; Gianneschi, N. C.; Mager, J.; Thayumanavan, S.
Bait-and-Switch Supramolecular Strategy to Generate Noncationic RNA–Polymer Complexes for RNA Delivery.
Biomacromolecules 2019, 20, 435–442.
DOI: 10.1021/acs.biomac.8b01321

32. Jiang, Z.; Cui, W.; Mager, J.; Thayumanavan, S.
Postfunctionalization of Noncationic RNA–Polymer Complexes for RNA Delivery.
Industrial & Engineering Chemistry Research 2019, 58, 6982–6991.
DOI: 10.1021/acs.iecr.9b00666

31. Gao, J.; Liu, X.; Secinti, H.; Jiang, Z.; Munkhbat, O.; Xu, Y.; Guo, X.; Thayumanavan, S.
Photoactivation of Ligands for Extrinsically and Intrinsically Triggered Disassembly of Amphiphilic Nanoassemblies.
Chemistry – A European Journal 2018, 24, 1789–1794.
DOI: 10.1002/chem.201705217

30. Bai, W.; Jiang, Z.; Ribbe, A. E.; Thayumanavan, S.
Smart Organic Two-Dimensional Materials Based on a Rational Combination of Non-covalent Interactions.
Angewandte Chemie International Edition 2016, 128(36), 10865–10869.
DOI: 10.1002/anie.201605050

29. Liu, X.; Hu, D.; Jiang, Z.; Zhuang, J.; Xu, Y.; Guo, X.; Thayumanavan, S.
Multi-Stimuli Responsive Amphiphilic Assemblies through Simple Post Polymerization Modification.
Macromolecules 2016, 49(17), 6186–6192.
DOI: 10.1021/acs.macromol.6b01397

28. Ray, M.; Brancolini, G.; Luther, D. C.; Jiang, Z.; Cao-Milán, R.; Cuadros, A. M.; Burden, A.; Clark, V.; Rana, S.; Mout, R.; Landis, R. F.; Corni, S.; Rotello, V. M.
High Affinity Protein Surface Binding through Co-engineering of Nanoparticles and Proteins.
Nanoscale 2022, 14, 2411–2418.
DOI: 10.1039/d1nr07497k

27. Zuraw-Weston, S.; Wood, D. A.; Torres, I. K.; Lee, Y.-W.; Wang, L.-S.; Jiang, Z.; Lázaro, G. R.; Wang, S.-Y.; Rodal, A. A.; Hagan, M. F.; Rotello, V. M.; Dinsmore, A. D.
Nanoparticles Binding to Lipid Membranes: from Vesicle-Based Gels to Vesicle Tubulation and Destruction.
Nanoscale 2019, 11, 18464–18474.
DOI: 10.1039/c9nr06570a

26. Huo, S.; Jiang, Y.; Jiang, Z.; Landis, R. F.; Liang, X.-J.; Rotello, V. M.
Stable and Oxidant Responsive Zwitterionic Nanoclusters.
Nanoscale 2018, 10, 7382–7386.
DOI: 10.1039/c7nr08951a

25. Freire, R. M.; Le, N. D. B.; Jiang, Z.; Kim, C. S.; Rotello, V. M.; Fechine, P. B. A.
NH2-rich Carbon Quantum Dots: A Protein-responsive Probe for Detection and Identification.
Sensors and Actuators B: Chemical 2018, 255, 2725–2732.
DOI: 10.1016/j.snb.2017.09.085

24. Tang, R.; Wang, M.; Ray, M.; Jiang, Y.; Jiang, Z.; Xu, Q.; Rotello, V. M.
Active Targeting of the Nucleus Using Non-Peptidic Boronate Tags.
Journal of the American Chemical Society 2017, 139, 8547–8551.
DOI: 10.1021/jacs.7b02801

23. Le, N. D. B.; Wang, X.; Geng, Y.; Tang, R.; Tonga, G. Y.; Jiang, Z.; Rotello, V. M.
Rapid and Ultrasensitive Detection of Endocrine Disrupting Chemicals Using a Nanosensor-enabled Cell-based Platform.
Chemical Communications 2017, 53, 8794–8797.
DOI: 10.1039/c7cc04561a

22. Tang, R.†; Jiang, Z.† (equal contribution); Ray, M.; Hou, S.; Rotello, V. M.
Cytosolic Delivery of Large Proteins Using Nanoparticle-stabilized Nanocapsules.
Nanoscale 2016, 8, 18038–18041.
DOI: 10.1039/c6nr07162g

21. Bag, M.†; Jiang, Z.† (equal contribution); Renna, L. A.; Jeong, S. P.; Rotello, V. M.; Venkataraman, D.
Rapid Combinatorial Screening of Inkjet-printed Alkyl-ammonium Cations in Perovskite Solar Cells.
Materials Letters 2016, 164, 472–475.
DOI: 10.1016/j.matlet.2015.11.058

20. Jiang, Z.; Bag, M.; Renna, L. A.; Jeong, S. P.; Rotello, V. M.; Venkataraman, D.
Aqueous-Processed Perovskite Solar Cells Based on Reactive Inkjet Printing.
hal.archives-ouvertes 2016, hal-01386295. (Preprint)
Link: hal.science/hal-01386295

19. Huo, S.; Jiang, Y.; Gupta, A.; Jiang, Z.; Landis, R. F.; Hou, S.; Liang, X.-J.; Rotello, V. M.
Fully Zwitterionic Nanoparticle Antimicrobial Agents through Tuning of Core Size and Ligand Structure.
ACS Nano 2016, 10(9), 8732–8737.
DOI: 10.1021/acsnano.6b04207

18. Hou, S.; Sikora, K. N.; Tang, R.; Liu, Y.; Lee, Y.-W.; Kim, S. T.; Jiang, Z.; Vachet, R. W.; Rotello, V. M.
Quantitative Differentiation of Cell Surface-Bound and Internalized Cationic Gold Nanoparticles Using Mass Spectrometry.
ACS Nano 2016, 10(7), 6731–6736.
DOI: 10.1021/acsnano.6b02105

17. Jiang, Z.; Le, D. B. N.; Gupta, A.; Rotello, V. M.
Cell Surface-based Sensing with Metallic Nanoparticles.
Chemical Society Reviews 2015, 44(13), 4264–4274.
DOI: 10.1039/c4cs00387j

16. Chen, J.†; Jiang, Z.† (equal contribution); Ackerman, J. D.; Yazdani, M.; Nugen, S. R.; Rotello, V. M.
Electrochemical Nanoparticle-Enzyme Sensors for Screening Bacterial Contamination in Drinking Water.
Analyst 2015, 140(15), 4994–4996.
DOI: 10.1039/c5an00637f

15. Ray, M.; Tang, R.; Jiang, Z.; Rotello, V. M.
Quantitative Tracking of Protein Trafficking to the Nucleus Enabled by Cytosolic Protein Delivery.
Bioconjugate Chemistry 2015,26(6), 1004–1007.
DOI: 10.1021/acs.bioconjchem.5b00141

14. Chen, J.; Alcaine. S. D.; Jiang, Z.; Rotello, V. M.; Nugen, S. R.
Detection of Escherichia coli in Drinking Water Using T7 Bacteriophage-conjugated Magnetic Probe.
Analytical Chemistry 2015, 87(17), 8977–8984.
DOI: 10.1021/acs.analchem.5b02175

13. Tonga, G. Y.; Mizuhara, T.; Saha, K.; Jiang, Z.; Hou, S.; Das, R.; Rotello, V. M.
Binding Studies of Cucurbit[7]uril with Gold Nanoparticles Bearing Different Surface Functionalities.
Tetrahedron Letters 2015, 56(23), 3653–3657.
DOI: 10.1016/j.tetlet.2015.04.125

12. Jiang, Y.; Tang, R.; Duncan, B.; Jiang, Z.; Yan, B.; Mout, R.; Rotello, V. M.
Direct Cytosolic Delivery of siRNA Using Nanoparticle-Stabilized Nanocapsules.
Angewandte Chemie International Edition 2015, 54(2), 506–510.
DOI: 10.1002/anie.201409161

11. Ding, Y.†; Jiang, Z.† (equal contribution); Saha, K.; Kim, C. S.; Kim, S. T.; Landis, R. F.; Rotello, V. M.
Gold Nanoparticles for Nucleic Acid Delivery.
Molecular Therapy 2014, 22(6), 1075–1083.
DOI: 10.1038/mt.2014.30

10. Li, X.; Robinson, S. M.; Gupta, A.; Saha, K.; Jiang, Z.; Moyano, D. F.; Sahar, A.; Riley, M. A.; Rotello, V. M.
Functional Gold Nanoparticles as Potent Antimicrobial Agents against Multi-Drug-Resistant Bacteria.
ACS Nano 2014, 8(10), 10682–10686.
DOI: 10.1021/nn5042625

9. Tang, R.; Moyano, D. F.; Subramani, C.; Yan, B.; Jeoung, E.; Tonga, G. Y.; Duncan, B.; Yeh, Y.-C.; Jiang, Z.; Kim, C.; Rotello, V. M.
Rapid Coating of Surfaces with Functionalized Nanoparticles for Regulation of Cell Behavior.
Advanced Materials 2014, 26(20), 3310–3314.
DOI: 10.1002/adma.201306030

8. Yang, Z.; Yang, H.; Jiang, Z.; Cai, T.; Li, H.; Li, H.B.; Li, A.; Cheng, R.
Flocculation of Both Anionic and Cationic Dyes in Aqueous Solutions by the Amphoteric Grafting Flocculant Carboxymethyl Chitosan-graft-polyacrylamide.
Journal of Hazardous Materials 2013, 254–255, 36–45.
DOI: 10.1016/j.jhazmat.2013.03.053

7. Yang, Z.; Yang, H.; Jiang, Z.; Huang, X.; Li, H.; Li, A.; Cheng, R.
A New Method for Calculation of Flocculation Kinetics Combining Smoluchowski Model with Fractal Theory.
Colloids and Surfaces A: Physicochemical and Engineering Aspects 2013,423, 11–19.
DOI: 10.1016/j.colsurfa.2013.01.058

6. Zhang, W.; Yang, H.; Dong, L.; Yan, H.; Li, H.; Jiang, Z.; Kan, X.; Li, A.; Cheng, R.
Efficient Removal of Both Cationic and Anionic Dyes from Aqueous Solutions Using a Novel Amphoteric Straw-based Adsorbent.
Carbohydrate Polymers 2012, 90(2), 887–893.
DOI: 10.1016/j.carbpol.2012.06.015

5. Zhang, W.; Li, H.; Kan, X.; Dong, L.; Yan, H.; Jiang, Z.; Yang, H.; Cheng, R.
Adsorption of Anionic Dyes from Aqueous Solutions Using Chemically Modified Straw.
Bioresource Technology 2012, 117, 40–47.
DOI: 10.1016/j.biortech.2012.04.064

4. Zhang, W.; Dong, L.; Yan, H.; Li, H.; Jiang, Z.; Kan, X.; Yang, H.; Li, A.; Cheng, R.
Removal of Methylene Blue from Aqueous Solutions by Straw Based Adsorbent in a Fixed-bed Column.
Chemical Engineering Journal 2011, 173(2), 429–436.
DOI: 10.1016/j.cej.2011.08.001

3. Yan, H.; Zhang, W.; Kan, X.; Dong, L.; Jiang, Z.; Li, H.; Yang, H.; Cheng, R.
Sorption of Methylene Blue by Carboxymethyl Cellulose and Reuse Process in a Secondary Sorption.
Colloids and Surfaces A: Physicochemical and Engineering Aspects 2011, 380(1–3), 143–151.
DOI: 10.1016/j.colsurfa.2011.02.045

2. Zhang, W.; Yan, H.; Li, H.; Jiang, Z.; Dong, L.; Kan, X.; Yang, H.; Li, A.; Cheng, R.
Removal of Dyes from Aqueous Solutions by Straw Based Adsorbents: Batch and Column Studies.
Chemical Engineering Journal 2011, 168(3), 1120–1127.
DOI: 10.1016/j.cej.2011.01.094

1. Li, H.; Kan, X.; Jiang, Z.; Zhang, W.; Yan H.; Yang H.; Cheng R.
Modified Straw Materials and Their Applications in Wastewater Treatment.
Chinese Polymer Bulletin 2011, 2, 21–29.
DOI: 10.14028/j.cnki.1003-3726.2011.02.015